Letrozole
- Model: steroid-39
- 1000 Kilogram in Stock
Company Name: Shanghai MeiHua
Certification: ISO9001, SGS, KOSHER
Delivery Time: 5~8 working days
Delivery Way: Domestic Delivery in Canada, Europe
Payment Terms: T/T, Western Union, Bitcoin
Email: sale@getraws.com
Details:
Trade Name: Femara
Bioavailability: 99.9%
Biological Half-life: 2 days
CAS Number: 112809-51-5
Formula: C17H11N5
Molar Mass: 285.303 g/mol
Assay: 99% Min
Character: White Crystalline Powder
Functions: Female Breast Cancer Treatment
State: Solid
Suitable for: Elderly, Adult
Delivery: Within 24hours After Your Payment
Domestic Delivery Service
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Introdcutions about Femara Letrozole
Letrozole is a type of hormone therapy drug used to treat breast cancer in women who have had their menopause. It is also called Femara. Letrozole is used treat early breast cancer in women who have experienced menopause (change of life; end of monthly menstrual periods) and who have had other treatments, such as radiation or surgery to remove the tumor. It is also used to treat early breast cancer in women who have experienced menopause and who have already been treated with a medication called tamoxifen (Nolvadex) for 5 years.
Letrozole is also used in women who have experienced menopause as a first treatment of breast cancer that has spread within the breast or to other areas of the body or in women whose breast cancer has worsened while they were taking tamoxifen. Letrozole is in a class of medications called non-steroidal aromatase inhibitors. It works by decreasing the amount of estrogen produced by the body. This can slow or stop the growth of some types of breast cancer cells that need estrogen to grow.
Femara Functions
Letrozole is used for the treatment of post-menopause breast cancer. Femara is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.Femara is intended for use only by women who are no longer of childbearing age. Possible candidates must have already ceased to menstruate. It is often used in patients who have already undergone other cancer treatments, such as radiation, chemotherapy, and used other cancer drugs, like tamoxifen.
Letrozole Functions Work Way
Letrozole lowers the levels of the female sex hormone oestrogen in the body. Oestrogen stimulates some breast cancers to grow. These breast cancers are called hormone sensitive or hormone receptor positive. Letrozole can stop or slow the growth of these cancers. It can also reduce the chance of a breast cancer coming back after surgery.
Letrozole only works in women who have had their menopause. It is a type of drug called an aromatase inhibitor. After the menopause, women don't produce oestrogen from their ovaries. But they still produce a small amount by using an enzyme called aromatase which turns other sex hormones called androgens into oestrogen. This change happens mainly in fatty tissue, muscle and the skin. Aromatase inhibitors block aromatase so that it can't change the androgen into oestrogen.
COA of Femara Letrozole
ANALYSIS |
SPECIFICATIONS |
RESULTS |
Assay |
98.0-102.0% |
99.8% |
CHEMICAL CONTROL
|
Identification
|
IR
HPLC
UV |
conform with standard IR conform
conform |
Related substances |
|
Related substances A |
0.3%(max) |
0.07% |
any other impurity |
0.1%(max) |
0.03% |
all other impurities |
0.3%(max) |
0.07% |
Organic volatile impurities |
Conforms with ICH requirements |
Residual solvents |
dichloromethane |
Nmt 600ppm |
complies |
Methanol |
Nmt 3000ppm |
complies |
Acetone |
Nmt 5000ppm |
complies |
ethanol |
Nmt 5000ppm |
complies |
PHYSICAL CONTROL |
Description |
White to yellowish, crystalline powder |
Complies |
Water by KF |
0.3%(max) |
0.13% |
Residue on ignition |
0.1%(max) |
0.04% |
Heavy metals |
0.001%(max) |
Complies |
|
STORAGE |
Cool and dry |
SHELF LIFE |
24 months |
Conclusion: It conforms to USP32